At the present time, IgG subclass deficiency is not a clearly defined disease. Some individuals with IgG subclass deficiency have no clinical disease, whereas others do. Recurrent sinusitis, otitis, pneumonia by Pneumococcus, Staphylococci, H.
influenzae develop at the patient of IgG4 deficiency.
We experienced two suspicious cases of IgG4 deficiency in a 16 months and a 32 months old male patients who were presented with recurrent respiratory tract infection history. At the immunological examination, the former decreased the level of
total
IgG
(not a deficiency level) and IgG4 the latter decreased the level of IgG4 with the normal level of total IgG.
We report two suspicious casesof IgG4 deficiency with brief review of related literature.
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